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Synthesis of Arcyriarubin A and Arcyriaflavin A via Cross-Coupling of Indolylboronic Acid with Dibromomaleimides |
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| Authors: | Ke Wang |
| Institution: | 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Beijing , China;2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China |
| Abstract: | Arcyriarubin A was first isolated by Steglich in 1980; it is also the key intermediate in the synthesis of indolocarbazole compounds. A new synthetic approach to the natural products arcyriaflavin A and arcyriarubin A is described. The key step is a Suzuki cross-coupling reaction using indolylboronic acid as the starting material. The preparation of arcyriaflavin A was accomplished in eight steps from indole for a total yield of 21%. |
| Keywords: | Arcyriaflavin A arcyriarubin A indolocarbazoles Suzuki coupling |