Synthesis of 1,2-Benzisoxazole 2-Oxides |
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| Authors: | Martin G Kociolek Olivia Hoermann |
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| Institution: | 1. Pennsyivania State Erie, Behrend College, School of Science , Erie , Pennsylvania , USA mgk5@psu.edu;3. Pennsyivania State Erie, Behrend College, School of Science , Erie , Pennsylvania , USA |
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| Abstract: | A series of 2-hydroxyaryl ketoximes were converted to the corresponding 1,2-benzisoxazole 2-oxides by treatment with iodobenzene diacetate (in acetic acid or methanol) or N-chlorosuccinimide in water. Both methods gave moderate to excellent yields for a variety of substituted oximes under mild conditions within short reaction times. The latter method has the advantages of an aqueous solvent and lack of halogenated organic by-products. |
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| Keywords: | Benzisoxazole 1 2-benzisoxazole 2-oxide iodobenzene diacetate N-chlorosuccinimide |
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