Catalytic Oxidation of Alcohols to Corresponding Aldehydes or Ketones with TEMPO-Mediated Iodosobenzene in Water in the Presence of a Surfactant |
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Authors: | Chenjie Zhu Lei Ji |
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Affiliation: | School of Chemical Engineering, Nanjing University of Science and Technology , Nanjing, China |
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Abstract: | An efficient, facile, and rapid oxidation of alcohols to the corresponding aldehydes or ketones with a stoichiometric amount of iodosobenzene (PhIO) in the presence of catalytic amounts of 2,2,6,6-tetramethyl-1-piperidinyloxyl free radical (TEMPO), KBr, and a surfactant, such as SDS (sodium dodecylsulfate), was reported. The oxidation proceeded in water at room temperature to afford aldehydes or ketones in excellent yields and high selectivity without overoxidation to carboxylic acids. Selective oxidation of primary alcohols in the presence of secondary alcohols was also achieved with the catalytic system of PhIO/TEMPO/KBr/SDS. A possible mechanism for the oxidation was supposed. |
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Keywords: | Alcohols iodosobenzene oxidation TEMPO water as solvent |
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