Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines |
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| Authors: | Giuseppe Cocconcelli Chiara Ghiron Simon Haydar Iolanda Micco |
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| Institution: | 1. Siena Biotech S.p.A. , Siena, Italy;2. Chemical Sciences and Neuroscience Discovery Research, Wyeth Research , Princeton, New Jersey, USA |
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| Abstract: | A new and efficient synthesis for the preparation of novel 4-fluoro-2H-pyrazol-3-ylamines is described. It involves the reaction of an acyl chloride with fluoroacetonitrile and sequential ring closure of the α-fluoro-β-ketonitrile with hydrazine. Utilizing this synthetic protocol, we have synthesized a variety of 4-fluoro-2H-pyrazol-3-ylamines with different steric and electronic demands. |
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| Keywords: | Aminopyrazole fluoro 4-fluoro-2H-pyrazol-3-ylamines |
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