Yamadazyma Farinosa IFO 10896-Mediated Reduction of 4,4-Dimethoxy-2-Butanone as the Key-Step for the Preparation of 1,3-Diols with Unsymmetrical Substituents |
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| Authors: | Takahiro Yamazaki Atsuhito Kuboki Hiromichi Ohta Thomas M Mitzel Leo A Paquette Takeshi Sugai |
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| Institution: | 1. Department of Chemistry , Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223–8522, Japan;2. Evans Chemical Laboratories, The Ohio State University , Columbus, Ohio, 43210, USA |
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| Abstract: | (R)-4,4-Dimethoxy-2-butanol was prepared with the action of Yamadazyma farinosa IFO 10896 on 4,4-dimethoxy-2-butanone, and subsequently converted to (2R,4R)- and (2R,4S)-isomers of 6-hepten-2,4-diol by the treatment with allyl bromide and indium in aqueous solution. |
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