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Chemistry of 3-Oxo-N-(pyridin-2-yl)butanamide and Related Compounds |
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| Authors: | Ahmed A Fadda Ebrahim Abdel-Galil Khaled M Elattar |
| Institution: | 1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egyptafadda50@yahoo.com;3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt;4. Chemistry Department, Faculty of Education, Sert University, Sert, Libya |
| Abstract: | This review highlights the methods used for the synthesis of 3-oxo-N-(pyridin-2-yl)butanamide compounds. The reactivity and synthetic importance are investigated. In this context, recent progress in the synthesis and use of 3-oxo-N-(pyridin-2-yl)butanamide as precursors for heterocyclic compounds is reviewed. The synthetic routes for preparation of 3-oxo-N-(pyridin-2-yl)butanamide are based on the reaction of diketene with aromatic primary amine and reaction of 2-aminopyridine with β-keto-t-butylthioester or ethylacetoacetate. The bibliography includes 73 references. |
| Keywords: | Biological importance 3-oxo-N-(pyridin-2-yl)butanamide pyridines reactions synthesis |