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Improved Method for the Preparation of Oxadiazoles from Diacyl Hydrazines |
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| Authors: | David Ellis Patrick S. Johnson Andrew Nortcliffe |
| Affiliation: | Sandwich Chemistry, Pfizer Global Research and Development , Sandwich, Kent, UK |
| Abstract: | N-methylimidazole (NMI) is used as the base in the triflic anhydride (Tf2O)–mediated formation of oxadiazoles from diacyl hydrazines. This reagent is superior to pyridine-derived bases in terms of cost and reaction profile. |
| Keywords: | Cyclization dehydration oxadiazoles |