An Efficient Synthesis of 15N-Hydroxyurea |
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| Authors: | Genichiro Yasaki Yueping Xu S Bruce King |
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| Institution: | Department of Chemistry , Wake Forest University , Winston-Salem , NC , 27109 Fax: E-mail: kingsb@wfu.edu |
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| Abstract: | Treatment of trimethylsilyl isocyanate with 15N-hydroxylamine hydrochloride produces 15N-hydroxyurea, a valuable pharmacological tool, in an efficient, one-pot procedure in 74% yield. Recrystallization of the crude product yields analytically pure material in 47% overall yield. |
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