Improved Methods for the Synthesis of Irbesartan,an Antihypertensive Active Pharmaceutical Ingredient |
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| Authors: | Korrapati V V Prasada Rao Vijay K Handa Inti V Subramanyeswara Rao Ananta Rani Andra Naidu |
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| Institution: | 1. Research and Development Department , Aurobindo Pharma Ltd. , Hyderabad, Andhra Pradesh, India;2. Jawaharlal Nehru Technological University , Hyderabad, India |
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| Abstract: | New methods for the preparation of irbesartan 1 have been described. The dehydration and tetrazole formation in one step from substituted cyclopentane derivative 7 with tributyltin chloride and sodium azide is described. Selective hydrolysis of nitrile 3 with HCl has also been described in the preparation of N‐acylaminocyclopentane‐2‐carboxylic acid 4, which is the key intermediate for the preparation of irbesartan. The impurity profiling of irbesartan has also been discussed. |
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| Keywords: | antihypertensive drug impurities irbesartan synthesis |
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