Efficient,Iron-Catalyzed Synthesis of 2-Mercaptobenzothiazole Through S-Arylation/Heterocyclization of 2-Haloaniline with Potassium Xanthate |
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| Authors: | Min Gao Chunqing Lou Weijing Qin Quanling Suo Limin Han |
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| Institution: | Chemical Engineering College, Inner Mongolia University of Technology, Hohhot, China |
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| Abstract: | A mild and practical method for the synthesis of 2-mercaptobenzothiazole has been developed by using iron as an efficient catalyst. The present tandem reaction process allows access to a wide range of 2-mercaptobenzothiazoles in good to excellent yields by the reaction of 2-haloaniline with potassium O-ethyl dithiocarbonate in the presence of FeF3 as a catalyst and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl as a ligand under an atmosphere of argon. |
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| Keywords: | 2-Haloaniline iron-catalyzed synthesis 2-mercaptobenzothiazole tandem reaction |
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