Enantioselective Synthesis of Chiral Propargylic Alcohols Catalyzed by Bifunctional Zinc-Based Complexes |
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| Authors: | Xinhua Lu Guanlei Xie Tingyi Li Xiaoming Qu |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou , P. R. China |
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| Abstract: | This work demonstrates an efficient way to prepare chiral propargylic alcohols by asymmetric addition of terminal Zn-acetylide to aldehydes catalyzed by bifunctional zinc-based complexes. The corresponding products with moderate to good yields and enantioselectivities were obtained in the absence of moisture-sensitive Ti(O i Pr)4. |
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| Keywords: | Alkyne asymmetric addition bifunctional complexes enantioselectivities |
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