First Synthesis of 5-Chloro-7-[1,3]oxazolo[4,5-b]pyridin-2-ylquinolin-8-ol by Pd-Catalyzed Arylation |
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| Authors: | Uthai Sakee Ronald Grigg |
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| Affiliation: | 1. Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science , Mahasarakham University , Mahasarakham, Thailand uthai.s@msu.ac.th;3. Molecular Innovation, Diversity, and Automated Synthesis (MIDAS) Centre, School of Chemistry , University of Leeds , Leeds, United Kingdom |
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| Abstract: | 5-Chloro-7-[1,3]oxazolo[4,5-b]pyridin-2-ylquinolin-8-ol was synthesized by a Pd-catalyzed arylation, which proceeds efficiently with 2 equivalents of benzylated clioquinol and 1 equivalent of oxazolo[4,5-b]pyridine. The product was smoothly debenzylated by boron trichloride in dichloromethane. |
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| Keywords: | Arylation clioquinol oxazolopyridine palladium synthesis |
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