K2CO3-Promoted Domino Reactions for Synthesis of Isocoumarins Under Microwave Irradiation |
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| Authors: | Yun-Hui Zhao Ming-Jian Luo Han-Wen Liu |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, China;2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, Chinazyh00041130@163.com hwyliu@126.com;4. Key Laboratory of Theoretical Chemistry and Molecular Simulation, Ministry of Education, China |
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| Abstract: | A small library of isocoumarin derivatives has been synthesized via K2CO3-catalyzed domino reactions of 2-carboxybenzaldehyde and ω-bromoacetophenones under microwave irradiation (MW). This strategy offers a simple, environmentally acceptable route to synthesize isocoumarin derivatives in moderate to excellent yields. All new compounds were characterized by 1H NMR, 13C NMR, infrared, and high-resolution mass spectroscopic techniques. |
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| Keywords: | ω-Bromoacetophenone" target="_blank">ω-Bromoacetophenone 2-carboxybenzaldehyde domino reactions isocoumarin microwave irradiation |
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