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Solvent‐Free Passerini Reactions
Authors:Dominik Koszelewski  Wiktor Szymanski  Joanna Krysiak
Institution:Institute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52, 01‐224, Warsaw, Poland
Abstract:The influence of the substrate structure and concentration on the yield of the Passerini reaction was studied. A new, solvent‐free methodology for a convenient preparation of α‐acyloxyamides 4 was established and compared to the classical methodology. A higher reaction yield was obtained in shorter time, especially in the case of aromatic aldehydes.
Keywords:α‐acyloxyamides  aromatic aldehydes  Passerini reaction  solvent free
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