Sc(OTf)3: A Highly Efficient and Renewable Catalyst for Michael Addition of Indoles to Nitroolefins in Water |
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| Authors: | Jianwei Xie Xinhai Zhu Manna Huang Fei Meng Man Wang |
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| Affiliation: | School of Chemistry and Chemical Engineering, Sun Yat-Sen University , Guangzhou, China |
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| Abstract: | A catalytic amount of scandium trifluoromethanesulfonate [Sc(OTf)3] (2.5 mol%) was used to catalyze the Michael addition of indoles to nitroolefins in water to afford the corresponding 3-alkylated indoles in good to excellent yields. The short reaction times, excellent yields, and renewability of the catalyst are noteworthy. |
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| Keywords: | Lewis acid Michael addition renewable catalyst scandium trifluoromethanesulfonate water |
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