Simple and Effective Synthetic Approach to Chiral 2-Amino-4-piperidinyl Pyridine Derivatives |
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Authors: | Hua Tian Qing-Wen Liu Hao Xu Wen-Bo Huang Jian Lin |
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Institution: | Department of Chemistry , Jilin University , Changchun , China |
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Abstract: | A facile way has been developed to provide a series of novel chiral N-(4-(piperidin-1-yl)pyridin-2-yl)amide derivatives as potential stereoselective catalysts. The key intermediate, 2-amino-4-piperidinyl pyridine, was obtained by nucleophilic substitution of 2-amino-4-chloropyridine with piperidine in good yields (up to 96%). The total control of enantioselectivity was obtained for the synthesis of L-proline and (R)-1,1′-bi(2-naphthol) derivatives. |
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Keywords: | 2-Amino-4-piperidinyl pyridine chiral catalysts DMAP PPY |
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