Determination of the Protonation Constants of Gadolinium(Iii) Diethyltriaminepentaacetic Acid by Solvent Extraction and Icp-Aes |
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| Authors: | Thomas J. Manning Warren Fiskus Mike Mitchell Leigh Dees |
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| Affiliation: | Department of Chemistry , Valdosta State University , Valdosta, Georgia, 31698 |
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| Abstract: | Abstract The first and second protonation constant (logβ111,logβ121 ) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25 °C and I = 0.1. A technique in which the three complexes (H2Gd-DTPA, HGd-DTPA?1, Gd-DTPA?2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration. |
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| Keywords: | magnetic resonance imaging contrast reagent protonation gadolinium DTPA |
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