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Synthesis and Spectral Characterization of Related Substances of Lacidipine,an Antihypertensive Drug |
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| Authors: | V. V. N. K. V. Prasada Raju Ganta Madhusudhan Reddy Vedantham Ravindra Vijayavitthal T. Mathad P. K. Dubey |
| Affiliation: | 1. Research and Development, Integrated Product Development , Dr. Reddy's Laboratories Ltd. , Hyderabad, India;2. Department of Chemistry , J. N. T. University , Hyderabad, India;3. Research and Development, Integrated Product Development , Dr. Reddy's Laboratories Ltd. , Hyderabad, India;4. Department of Chemistry , J. N. T. University , Hyderabad, India |
| Abstract: | Five related substances (impurities) were detected in lacidipine bulk drug substance by a simple high-performance liquid chromatographic method (HPLC) and were identified by liquid chromatography–mass spectrometry (LC-MS). These related substances were independently synthesized, characterized, and co-injected with the sample containing impurities. |
| Keywords: | Antihypertensive drug lacidipine related substances spectral characterization synthesis |