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Trifluoroethanol as a Metal-Free,Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones |
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| Authors: | S. V. Rashmi N. C. Sandhya B. Raghava M. N. Kumara K. Mantelingu |
| Affiliation: | Department of Studies in Chemistry , University of Mysore , Mysore , India |
| Abstract: | Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst. |
| Keywords: | Biginelli reaction cyclization homogeneous catalysis multicomponent trifluoro ethanol |