Synthesis of Some Functionalized Peptomers via Ugi Four-Component Reaction |
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Authors: | Eduardo H. B. Silva Flavio S. Emery Gino Del Ponte |
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Affiliation: | 1. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeir?o Preto, Universidade de S?o Paulo, Ribeir?o Preto, Brazil;2. Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeir?o Preto, Universidade de S?o Paulo, Ribeir?o Preto, Brazil |
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Abstract: | This article describes the synthesis of new peptomers through a simple and efficient route using a one-pot Ugi four-component reaction. The synthesis started from either carboxylic acids or protected amino acids, primary amines, aldehydes, and isocyanides in anhydrous methanol and proceeded under stirring at room temperature. The reaction produced several functionalized peptomers in good yields (67–80%). These compounds are versatile multifunctional intermediates that can be further unprotected or functionalized to generate new molecules with numerous applications in the field of biomedicine. |
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Keywords: | Diversity-oriented synthesis MCR multicomponent reaction one-pot reaction peptoid peptomer Ugi reaction |
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