Three-Component Reaction of Triphenylphosphine,Dialkyl Acetylenedicarboxylate,and 2-Aminothiazole or 2-Aminobenzothiazole in the Presence of Arylglyoxals: An Efficient One-Pot Synthesis of Highly Functionalized Pyrroles |
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| Authors: | Mohammad Anary-Abbasinejad Hamidreza Dehghanpour Farashah Hossein Anaraki-Ardakani Nasim Shams |
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| Institution: | 1. Department of Chemistry , Rafsanjan Vali-e-Asr University , Rafsanjan , Iran;2. Department of Chemistry , Islamic Azad University , Yazd Branch , Yazd , Iran;3. Department of Chemistry , Islamic Azad University, Mahshahr Branch , Mahshahr , Iran |
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| Abstract: | A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction of dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminothiazole or 2-aminobenzothiazole in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded good yields of products. |
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| Keywords: | 2-Aminobenzothiazole 2-aminothiazole arylglyoxals dialkyl acetylenedicarboxylates intramolecular Wittig reaction multicomponent reaction pyrrole derivatives triphenylphosphine |
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