Synthesis of [1,2,3]Triazolo[5,1-a]isoquinoline Derivatives via a Selective Cascade Cyclization Sequence of 1,2-bis(Phenylethynyl)benzene Derivatives |
| |
Authors: | Shipeng Tao Qinquan Hu Huan Li Shan Ma |
| |
Institution: | School of Chemical and Environmental Engineering, Wuhan Institute of Technology, Wuhan, China |
| |
Abstract: | A direct, concise, synthetic method for the generation of 1,2,3]triazolo5,1-a]isoquinoline derivatives, using a selective cascade cyclization of unsymmetrical substituted 1,2-bis(phenylethynyl)benzene derivatives with NaN3, has been developed. The reaction gave different substituted 1,2,3]triazolo5,1-a]isoquinolines in moderate to good yields. It was found that the substituents on the alkynes were important for the selectivities of the cascade cyclization sequences. |
| |
Keywords: | Cascade reaction cyclization 1 2 3-triazole [1 2 3]triazolo[5 1-a]isoquinoline |
|
|