1,4-Diazabicyclo[2.2.2]octane as an Efficient Catalyst for a Clean,One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives via Multicomponent Reaction in Aqueous Media |
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| Authors: | Daryoush Tahmassebi Jessica A Bryson Sophia I Binz |
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| Institution: | 1. Chemistry Department , Indiana University–Purdue University Fort Wayne , Fort Wayne , Indiana , USA tahmassd@ipfw.edu;3. Chemistry Department , Indiana University–Purdue University Fort Wayne , Fort Wayne , Indiana , USA |
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| Abstract: | 1,4-Diazabicyclo2.2.2]octane (DABCO) has been used as a mild and efficient catalyst for the synthesis of various tetrahydrobenzob]pyran derivatives via a one-pot, three component condensation of aromatic aldehydes, dimedone, and active methylene compounds. This method provides several advantages: a simple workup procedure, environmental friendliness, neutral conditions, and good yields. In addition, water or 50% aqueous ethanol was chosen as a green solvent.  Additional information ACKNOWLEDGMENT This work was supported by an Indiana University–Purdue University Fort Wayne Summer Faculty Research Grant. |
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| Keywords: | Active methylene compound aromatic aldehyde dimedone multicomponent reaction tetrahydrobenzo[b]pyran |
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