Cyclic Ketones in Spiroannulation |
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| Authors: | Vidar Bj?rnstad |
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| Institution: | Department of Chemistry , University of Oslo , Oslo, Norway |
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| Abstract: | Conversion of a cyclic carbonyl carbon into a quaternary carbon has been effected by a Wittig–Horner reaction with diethyl (N-benzyliden)aminomethylphosphonate and a subsequent alkylation with a protected vinyl ketone. The product was a substrate for spiroannulation after initial hydrolysis. The reaction sequence was carried out as a one-pot reaction. |
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| Keywords: | Addition reactions carbonyl quaternization lithiation spiroannulation Wittig–Horner reaction |
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