Efficient NaOH-Catalyzed Reaction of Aromatic Aldehyde,Cyclic Ketones,and Malononitrile Under Solvent-Free Conditions Using a Grinding Method |
| |
| Authors: | Liangce Rong Hongxia Han Hong Jiang Shujiang Tu |
| |
| Affiliation: | 1. College of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou, Jiangsu, P.R. China;2. The Key Laboratory of Biotechnology for Medicinal Plants , Xuzhou, Jiangsu, P.R. China lcrong2005@yahoo.com;4. College of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou, Jiangsu, P.R. China;5. The Key Laboratory of Biotechnology for Medicinal Plants , Xuzhou, Jiangsu, P.R. China;6. The Key Laboratory of Biotechnology for Medicinal Plants , Xuzhou, Jiangsu, P.R. China |
| |
| Abstract: | An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions. |
| |
| Keywords: | 2,6-Dicyanoanilines green chemistry grinding solvent free synthesis |
|
|
