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Unexpected Synthesis of Highly Substituted Indole Derivatives |
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| Authors: | Rajeshwar Reddy Sagyam Himabindu Vurimidi Pratap Reddy Padi Katkam Srinivas |
| Affiliation: | 1. Integrated Product Development, Dr. Reddy's Laboratories Limited , Bachupally, Qutubullapur, India;2. Institute of Science and Technology, Center for Environmental Science, J. N. T. University , Hyderabad, India |
| Abstract: | An unexpected synthesis of highly substituted indole derivatives was provided by treating 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with aryl hydrazines in the presence of trifluoroacetic acid in tetrahydrofuran. |
| Keywords: | Aryl hydrazine cyclization 1,4-diketone hydrazine hydrate indole 1,2-pyridazine |