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Facile Synthesis of 6-Aryl-3-cyanopyridine-2-(1H)-thiones from Aryl Ketones |
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| Authors: | Ren-Lin Zheng Xiu-Xiu Zeng Hai-Yun He Jun He Sheng-Yong Yang Luo-Ting Yu |
| Affiliation: | 1. State Key Laboratory of Biotherapy and Cancer Center , West China Hospital, West China Medical School, Sichuan University , Chengdu , China;2. State Key Laboratory of Biotherapy and Cancer Center , West China Hospital, West China Medical School, Sichuan University , Chengdu , China;3. Department of Pharmaceutical and Bioengineering , School of Chemical Engineering, Sichuan University , Chengdu , China;4. Department of Pharmaceutical and Bioengineering , School of Chemical Engineering, Sichuan University , Chengdu , China |
| Abstract: | An improved synthesis of 6-aryl-3-cyanopyridine-2-(1H)-thiones utilizing enaminones as starting materials catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) was described. Moreover, a convenient one-pot conversion of aryl ketones to 6-aryl-3-cyanopyridine-2-(1H)-thiones was also developed in moderate to good yields (up to 80%). |
| Keywords: | 6-Aryl-3-cyanopyridine-2-(1H)-thiones DABCO enaminones one-pot synthesis |