One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Directly from Nitrile and Hydroxylamine Hydrochloride Under Solvent-Free Conditions Using Potassium Fluoride as Catalyst and Solid Support |
| |
| Authors: | Shahnaz Rostamizadeh Hamid Reza Ghaieni Reza Aryan Ali-Mohammad Amani |
| |
| Institution: | 1. Department of Chemistry , K. N. Toosi University of Technology , Tehran, Iran shrostamizadeh@yahoo.com;3. Department of Chemistry , K. N. Toosi University of Technology , Tehran, Iran;4. Faculty of Material and Chemical Engineering, Malek Ashtar University of Technology , Tehran, Iran;5. Department of Chemistry , K. N. Toosi University of Technology , Tehran, Iran |
| |
| Abstract: | A one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles with two identical substituents directly from the reaction of nitriles and hydroxylamine hydrochloride in the presence of potassium fluoride as catalyst and solid support under solvent-free condition is described. Moreover, the formation of products has been discussed, and a plausible mechanism has been presented. Simplicity of the process, workup in aqueous media, and excellent yields are some advantages of this method. |
| |
| Keywords: | Amidoximes nitriles one-pot reaction 1 2 4-oxadiazole potassium fluoride solvent-free condition |
|
|
