Selective Decarboxylation: A Facile Synthesis of 3-Pyridinecarboxylic Acid Derivative |
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| Authors: | Junhua Wang Honglin Wang Hongmin Ren Lihua Dong |
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| Affiliation: | 1. Institute of Marine Material Science and Engineering, Shanghai Maritime University , Shanghai, China chemwoods@yahoo.com.cn;3. School of Chemistry, Yunnan University , Kunming, China;4. Institute of Marine Material Science and Engineering, Shanghai Maritime University , Shanghai, China |
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| Abstract: | A convenient synthesis of 5-trifluoromethyl-3-pyridinecarboxylic acid was developed, involving palladium-catalyzed carbonylation, hydrolysis, and decarboxylation. This novel route features inexpensive starting material and easy operations. |
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| Keywords: | Decarboxylation hydrolysis pyridinecarboxylic acid |
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