Catalytic Synthesis of Fused 1,4-Dihydropyridines and 1,4-Dihydropyridine Derivatives Using Preyssler Heteropolyacids Catalyst |
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| Authors: | Ali Gharib Manouchehr Jahangir Mina Roshani J. W. Scheeren |
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| Affiliation: | 1. Department of Chemistry , Islamic Azad University , Mashhad , Iran;2. Agricultural Researches and Services Center , Mashhad , Iran aligharib5@yahoo.com;4. Department of Chemistry , Islamic Azad University , Mashhad , Iran;5. Cluster for Molecular Chemistry, Department of Organic Chemistry , Radboud University, Nijmegen , The Netherlands |
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| Abstract: | An efficient and convenient method for the synthesis of 1,4-dihydropyridines from β-dicarbonyl compounds, aldehydes, and ammonium acetate and the synthesis of fused 1,4-dihydropyridines from dimedone in the presence of Preyssler heteropolyacid catalyst are reported under reflux conditions with good to excellent yields. Preyssler heteropolyacid catalyst is easily prepared, stable (up to 300 °C), reusable, efficient, green and inexpensive. |
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| Keywords: | 1,4-Dihydropyridines dimedone Hantzsch reaction heteropolyacid Preyssler |
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