Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs |
| |
Authors: | Sergey V Ryabukhin Andrey S Plaskon Dmitriy M Volochnyuk Sergey E Pipko Andrey A Tolmachev |
| |
Institution: | 1. Enamine Ltd. , Kyiv, Ukraine;2. National Taras Shevchenko University , Kyiv, Ukraine Ryabukhin@mail.enamine.net;4. National Taras Shevchenko University , Kyiv, Ukraine;5. Institute of Organic Chemistry, National Academy of Sciences of Ukraine , Kyiv, Ukraine;6. Enamine Ltd. , Kyiv, Ukraine;7. National Taras Shevchenko University , Kyiv, Ukraine |
| |
Abstract: | A facile one-pot method for the synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids and their heterocyclic analogs based on the tert-amino effect. A set of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids was readily prepared starting from various ortho-dialkylaminoaldehydes and Meldrum's acid using Me3SiCl in dimethylformamide (DMF) solution. |
| |
Keywords: | Chlorotrimethylsilane Meldrum's acid ortho-dialkylaminoaldehydes 1 2 3 4-tetrahydroquinoline-3-carboxylic acids tert-amino effect |
|
|