Synthesis of 2‐Alkyl‐Substituted Benzimidazoles by Thermal Decomposition of 2‐Azidobenzenamines in thePresence of an Aldehyde |
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| Authors: | Jeffery M Wallace Jeremiah W Hubbard |
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| Institution: | C. Eugene Bennett Department of Chemistry , West Virginia University , Morgantown, West Virigina, USA |
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| Abstract: | 2‐Substituted benzimidazoles were prepared by reaction of 2‐azidoaminobenzenes with aldehydes under thermal conditions. The reaction probably proceeds via a sequential imine formation, azide decomposition forming a nitrene, and electrocyclization. |
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| Keywords: | Alkaloids azide benzimidazole nitrene |
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