Facile One-Pot,Multicomponent Synthesis of Pyridines Under Microwave Irradiation |
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| Authors: | Jian-Feng Zhou Yuan-Zhi Song Jin-Shun Lv Gui-Xia Gong Shujiang Tu |
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| Institution: | 1. Department of Chemistry , Huaiyin Teachers College, Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials , Huaian, China;2. School of Chemistry and Chemical Engineering , Suzhou University , Suzhou, China orgjfzhou@yahoo.com.cn;4. Department of Chemistry , Huaiyin Teachers College, Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials , Huaian, China;5. School of Chemistry and Chemical Engineering , Suzhou University , Suzhou, China;6. Department of Chemistry , Xuzhou Normal University , Xuzhou, China |
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| Abstract: | A series of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-pyridine-3-carbo-nitriles were synthesized by the one-pot, multicomponent reaction of 3-acetyl-coumarin, aromatic aldehydes, malononitrile, and ammonium acetate in acetic acid under microwave irradiation. The reactions were completed in 10–13 min with 61–86% yields, were environmental benign, and had easy workup. Their structures were confirmed by 1H NMR, IR, and MS spectra and elemental analysis. |
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| Keywords: | 3-Acetylcoumarin 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-pyridine-3-carbonitrile microwave irradiation multicomponent reaction |
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