Novel,Efficient, and Green Procedure for the Knoevenagel Condensation Catalyzed by Diammonium Hydrogen Phosphate in Water |
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| Authors: | Saeed Balalaie Morteza Bararjanian Shohreh Hekmat Peyman Salehi |
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| Affiliation: | 1. Department of Chemistry , K.N. Toosi University of Technology , Tehran, Iran balalaie@kntu.ac.ir;3. Department of Chemistry , K.N. Toosi University of Technology , Tehran, Iran;4. Department of Chemistry , Islamic Azad University , North Tehran Branch, Iran;5. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute , Shahid Beheshti University , Evin, Tehran, Iran |
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| Abstract: | Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammonium hydrogen phosphate. The reactions were carried out at room temperature in short periods with very simple workup procedure and good to high yields. |
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| Keywords: | Alkene diamamonium hydrogen phosphate Knoevenagel condensation water |
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