Efficient Synthesis of Thalifoline and Its Analogs |
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| Authors: | Qiang Li Si-Cen Wang Ming-Zhe Zhou |
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| Affiliation: | School of Medicine, Xi'an Jiaotong University , Xi'an, China |
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| Abstract: | Thalifoline (1) and its analogs were synthesized from methyl 3-hydroxy-4-methoxy benzoate by prenyl etherification, Claisen rearrangement, oxidation, imine formation, reductive amination and intramolecular amidation. The last three steps, imine formation, reductive amination, and intramolecular amidation, were completed in one pot at room temperature. |
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| Keywords: | Claisen rearrangement intramolecular amidation isoquinolinone one-pot method thalifoline |
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