One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles Using MoO3/SiO2, an Efficient and Recyclable Catalyst |
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| Authors: | Sidhanath V Bhosale Mohan B Kalyankar Santosh V Nalage Dattatry S Bhosale Swati L Pandhare Trupti V Kotbagi |
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| Institution: | 1. Department of Organic Chemistry , North Maharashtra University , Jalgaon , India sidhanath2003@yahoo.co.in;3. Department of Organic Chemistry , North Maharashtra University , Jalgaon , India;4. Organic Chemistry Division, National Chemical Laboratory , Pune , India;5. Catalysis Division, National Chemical Laboratory , Pune , India |
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| Abstract: |  A simple one-pot synthesis has been developed for the synthesis of 2,4,5-trisubstituted imidazoles using an efficient and recyclable MoO3/SiO2 solid acid catalyst by condensation of benzil or benzoin, benzaldehyde, and ammonium acetate in acetonitrile as a solvent. Using this solid catalyst, the reactions could be carried out under mild reaction conditions with very good yield of imidazoles, up to 95%. This catalyst could be recycled very easily, which makes this methodology environmentally benign. |
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| Keywords: | Benzil/benzoin cyclocondensation imidazoles MoO3/SiO2 one-pot solid acid |
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