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One-Pot Synthesis of 4-Aminoquinazolines by Hexamethyldisilazane-Mediated Reaction of Quinazolin-4(3H)-ones with Amines |
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| Authors: | Zhen-Lu Shen Xiao-Fei He Yi-Ming Hong Xin-Quan Hu Bao-Xiang Hu |
| Affiliation: | 1. College of Chemical Engineering and Materials Science , Zhejiang University of Technology , Hangzhou , China zhenlushen@zjut.edu.cn;3. College of Chemical Engineering and Materials Science , Zhejiang University of Technology , Hangzhou , China |
| Abstract: | Hexamethyldisilazane-mediated reaction of quinazolin-4(3H)-ones with primary amines led to facile formation of 4-aminoquinazolines through tandem silylation and substitution in a single pot. Excellent yields of the products (83–97%) and environmental friendliness (avoiding the use of chlorination reagents) are the advantages of this method.  |
| Keywords: | Amination aminoquinazolines hexamethyldisilazane quinazolin-4(3H)-ones |