Elegant Synthesis of Highly Functionalized 1,2,3-Trisubstituted Cyclopentanes |
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| Authors: | Fatma Saâdi Aïcha Arfaoui |
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| Institution: | Department of Chemistry , Tunis El Manar University, Faculty of Science , Tunis , Tunisia |
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| Abstract: | The conversion of cyclic Baylis–Hillman acetates 1 into the corresponding cyano derivatives 2 was achieved using potassium cyanide in the presence of 1,4-diazabicyclo2.2.2]octane (DABCO) in aqueous medium. The obtained Michael acceptors 2 easily add primary amines in absolute ethanol to produce a new family of 1,2,3-trisubstituted cyclpentanes 3 in good yields. |
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| Keywords: | Baylis–Hillman acetates DABCO primary amines 1 2 3-trisubstituted cyclopentanes |
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