Malonic Ester Amide Synthesis: An Efficient Methodology for Synthesis of Amides |
| |
Authors: | Pankaj S. Mahajan Jyoti P. Mahajan |
| |
Affiliation: | National Chemical Laboratory (CSIR-NCL) , Division of Organic Chemistry , Pune , India |
| |
Abstract: | A general methodology “malonic ester amide synthesis” has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
| |
Keywords: | Amide synthesis aromatic amines condensation decarboxylation diethyl malonates |
|