Improved Synthesis of the ORL Antagonist 1-[(3R,4R)-1-Cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) |
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| Authors: | F. Ivy Carroll Lawrence E. Brieaddy |
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| Affiliation: | 1. Center for Organic and Medicinal Chemistry, Research Triangle Institute , Research Triangle Park, North Carolina, USA fic@rti.org;3. Center for Organic and Medicinal Chemistry, Research Triangle Institute , Research Triangle Park, North Carolina, USA |
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| Abstract: | A practical synthesis of optically pure 1-[(3R,4R)-1-cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) was developed that avoids the use of chiral columns. |
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| Keywords: | Antagonist Chiral auxiliary J-113397 ORL-1 Synthesis |
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