Envirocat EPZ-10: A Solid Acid Catalyst for the Synthesis of 1,8-Dioxo-octahydroxanthenes in Aqueous Medium |
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| Authors: | D. M. Pore T. S. Shaikh N. G. Patil S. B. Dongare U. V. Desai |
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| Affiliation: | 1. Department of Chemistry , Shivaji University , Kolhapur, India p_dattaprasad@rediffmail.com;3. Department of Chemistry , Shivaji University , Kolhapur, India |
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| Abstract: | An efficient method for synthesis of 1,8-dioxo-octahydroxanthenes using EPZ-10 as a heterogeneous catalyst is developed. In this method, aldehydes and dimedone / cyclohexane-1,3-dione are heated at 70 °C in the presence of a catalytic amount of EPZ-10 in water as a universal solvent, affording the corresponding 1,8-dioxo-octahydroxanthenes in moderate to excellent yields. Also, domino Knoevenagel / hetero-Michael-addition reaction is described in water without any catalyst with excellent yields. The major advantages of this method are excellent yields, short reaction time, and ease of operation. This green protocol works well with dimedone as well as cyclohexane-1,3-dione. |
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| Keywords: | 1,8-Dioxo-octahydroxanthenes domino reaction Envirocat EPZ-10 heterogeneous catalyst xanthenedione derivatives |
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