New Chiral Aminoamidoximes: Syntheses and Investigation of Heterocyclic Compounds |
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Authors: | Najeh Tka |
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Institution: | Laboratoire de Synthèse Organique Asymétrique et Catalyse Homogène, Faculté des Sciences de Monastir , Monastir , Tunisia |
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Abstract: | New chiral aminoamidoximes were prepared from (L)-proline, (L)-alanine, and (L)-isoleucine by treatment of the corresponding aminonitriles with hydroxylamine in the presence of triethylamine. The intramolecular cyclization with α-bromoacid chlorides and aldehydes was investigated to give new 1,2,4-oxadiazin-6-ones and 1,2,4-oxadiazoles, respectively. These compounds were likely to undergo an intermolecular cyclization through oxygen and nitrogen. However, intramolecular cyclization through two nitrogens did not occur even after changing reaction conditions. |
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Keywords: | Aminoamidoximes intramolecular cyclization 1 2 4-oxadiazin-6-ones 1 2 4-oxadiazoles |
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