Efficient and Straightforward Synthesis of Tetrahydrocarbazoles and 2,3-Dimethyl Indoles Catalyzed by CAN |
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Authors: | P Prabhakara Varma Bailure S Sherigara Vijaykumar Hulikal |
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Institution: | 1. Department of Postgraduate Studies and Research in Industrial Chemistry and Chemistry, School of Chemical Sciences , Kuvempu University , Shankaraghatta, Karnataka, India;2. Bioorganics and Applied Materials , Bangalore, India |
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Abstract: | A simple protocol was established to synthesize 2,3-dialkyl indoles and various tetrahydrocarbazoles via Fischer indole synthesis. This method uses ceric ammonium nitrate as a catalyst for the Fischer indole synthesis with substituted phenyl hydrazine hydrochlorides and 2-butanone, phenyl propanal, and cyclohexanone. This process is a practical synthetic method for the preparation of various 2,3-disubstituted alkyl indoles and tetrahydrocarbazoles. |
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Keywords: | CAN Fischer indole synthesis Lewis acids one pot phenylhydrazine hydrochlorides |
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