Nickel-Catalyzed C-Br/C-H Bis-phenylation of Methyl 4-Bromocrotonate: A Stereoselective Entry to Methyl (E)-3,4-Diphenylbut-2-enoate |
| |
| Authors: | Maria Funicello Lucia Chiummiento Paolo Lupattelli Francesco Tramutola |
| |
| Affiliation: | 1. Dipartimento di Scienze, Università degli Studi della Basilicata, Potenza, Italymaria.funicello@unibas.it;3. Dipartimento di Scienze, Università degli Studi della Basilicata, Potenza, Italy |
| |
| Abstract: | A method for C-Br/C-H bis-phenylation of methyl 4-bromocrotonate via nickel-catalyzed cross-coupling reaction has been developed. This protocol involves commercially available catalyst components and furnishes a suitable doubly phenylated building block. |
| |
| Keywords: | Boronic acids cross-coupling nickel phenylation stereoselectivity |
|
