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Efficient Synthesis of Quinolines via a Knoevenagel/Staudinger/aza-Wittig Sequence |
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| Authors: | Feng Qu Ruo-Fei Hu Xiao-Hong Cheng Song Wang Jing Wu |
| Institution: | 1. College of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, China;2. Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, China |
| Abstract: | A simple and efficient method for the construction of quinoline derivatives from 2-azidobenzaldehyde and various carbonyl compounds was developed. The process involves a Knoevenagel condensation of 2-azidobenzaldehyde with carbonyl compound and subsequently an intramolecular normal Staudinger/aza-Wittig reaction to form the quinolone ring in satisfactory yields. |
| Keywords: | 2-Azidobenzaldehyde Knoevenagel/aza-Wittig reaction quinolones |