Expedient Synthesis,on Large Scale,of Aliphatic Chaetomellic Anhydrides from N-Allyl-2,2-dichlorocarboxyamides |
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| Authors: | Franco Ghelfi Mariella Pattarozzi Fabrizio Roncaglia Valerio Giangiordano Andrew F Parsons |
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| Institution: | 1. Department of Chemistry , University of the Studies of Modena and Reggio Emilia , Modena, Italy franco.ghelfi@unimore.it;3. Department of Chemistry , University of the Studies of Modena and Reggio Emilia , Modena, Italy;4. Department of Chemistry , University of York , Heslington, York, United Kingdom |
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| Abstract: | Chaetomellic anhydride A and an analog (with two additional carbons) were obtained, on a preparative scale, starting from amides derived from the acylation of 2-(2-propenylamino)pyridine with 2,2-dichloropalmitic or 2,2-dichlorostearic acid. An alternative approach, in which the methyl substituent of the target anhydride is introduced by the carboxylic acid reactant and the long aliphatic chain is added through the allylamino moiety, proved unviable. |
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| Keywords: | Chaetomellic anhydride halocompounds lactams radical reactions |
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