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Efficient Method for Demethylation of Aryl Methyl Ether Using Aliquat-336 |
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| Authors: | Suresh B. Waghmode Ganesh Mahale Viraj P. Patil Kartik Renalson Dharmendra Singh |
| Affiliation: | 1. Department of Chemistry , University of Pune , Pune , India suresh@chem.unipune.ac.in;3. Department of Chemistry , University of Pune , Pune , India;4. IPCA Laboratories , Kandivali Industrial Estate Charkop , Kandivali West , Mumbai , India |
| Abstract: | A rapid method for selective cleavage of aryl methylethers can be achieved in the presence of a protic acid and a catalytic amount of phase-transfer catalyst (Aliquat-336). Aliquat-336 accelerates the rate of reaction and affords the corresponding phenols in excellent to good yields on a wide variety of substrates. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
| Keywords: | Aliquat-336 aryl methyl ethers demethylation hydrobromic acid PTC |