Synthesis of Novel Saccharide Hydrazones |
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| Authors: | Mihkel Ilisson Kristjan Tomson Anastasia Selyutina Silver Türk |
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| Affiliation: | 1. Institute of Chemistry, University of Tartu, Tartu, Estonia;2. Institute of Technology, University of Tartu, Tartu, Estonia;3. Faculty of Medicine, University of Tartu, Tartu, Estonia |
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| Abstract: | Synthesis of important heterocyclic hydrazine derivatives N-aminopyrrolidine, N-aminopiperidine, and N-aminoazepane from hydrazine hydrate and dihalogenides were examined and optimized. These heterocyclic hydrazine derivatives were used in condensation reactions with six different monosaccharides to form corresponding hydrazones. Biological evaluations of these novel compounds, which are simple acyclic nucleoside analogs, were done. L-Arabinose N-aminoazepane hydrazone showed minor anti-HIV activity, giving a starting point for further structural modifications. |
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| Keywords: | Heterocycle HIV hydrazine hydrazone saccharide |
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