Convenient Synthesis of 6-Bromo-1,2,3,4-tetrahydroisoquinoline and 3-Methoxy-1,2,3,4-tetrahydro-[2,7]-naphthyridine via Reductive Amination of Schiff's Bases |
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| Authors: | Pavol Zlatoidský Bálint Gábos |
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| Institution: | 1. AstraZeneca AB, Discovery Lund , Lund, Sweden Pavol.Zlatoidsky@astrazeneca.com;3. AstraZeneca AB, Discovery Lund , Lund, Sweden |
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| Abstract: | Synthesis of 7-bromo-1,2,3,4-tetrahydroisoquinoline and 6-methoxy-1,2,3,4-tetrahydro-2,7]-naphthyridine via lithiation of 2-methylarylidene-tert-butylamines, followed by formylation, reductive amination in one-pot, and removal of the tert-butyl group from the nitrogen, is described. |
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| Keywords: | Cyclization formylation lithiation reductive amination |
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