One-Pot Synthesis of N2-Substituted 2-Amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitrile in Basic Ionic Liquid [bmim]OH |
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| Authors: | Yu Wan Rui Yuan Fu-Ren Zhang Li-Ling Pang Rui Ma Cai-Hui Yue |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou , P. R. China;2. Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province , Jiangsu , P. R. China;3. School of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou , P. R. China |
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| Abstract: | N2-Methyl- or aryl-substituted 2-amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized via a four-component, one-pot reaction of aromatic aldehyde, cyclohexanone, malononitrile, and amines in basic ionic liquid bmim]OH with good to excellent yields. During this transformation, at least 11 bonds were cleaved and 7 new bonds were constructed.  |
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| Keywords: | [bmim]OH synthesis tetrahydroquinoline |
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